ACE-2

• Description :

  The protein encoded by the gene ACE belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.

• Synonyms :

  ACE2; ACEH

• NCBI Gene ID :

  59272

• UniProt :

  Q9BYF1

• Accession Number :

  NP_068576.1

• Accession Number mRNA :

  NM_021804

• Chromosomal Location :

  Xp22

• Reactivity :

  Anti-Human

• Cross Reactivity :

  Human

• Target Antigen :

  Human ACE-2 recombinant protein (extracellular domain)

• Clone :

  (#11A31)

• Applications :

  WB, IHC (P)

• Purification Method :

  Protein G chromatography

• Assay Protocol :

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form :

  Lyophilized

• Buffer :

  PBS

• Reconstitution :

  PBS

• Storage Conditions :

  Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source :

  Mouse

• Isotype :

  IgG2