Mouse Anti-Human ACE Monoclonal Antibody
CAT:
209-101-M200
Size:
100 µg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Mouse Anti-Human ACE Monoclonal Antibody
- Description: Angiotensin I Converting Enzyme (ACE, also known as peptidyl-dipeptidase A, kininase II, or CD143) is a type I transmembrane zinc metallopeptidase that is important in the metabolism of the vaso-active peptides angiotensin II and bradykinin. Two isoforms of ACE that exhibit distinct physiologic functions have been described: germinally expressed ACE (gACE) and somatic cell expressed ACE (sACE). Both isoforms are transcribed from a single gene using alternative promoters. The gACE isoform is exclusively expressed in the testes, whereas sACE is expressed on endothelial cells, epithelial cells, neuronal cells, and dendritic cells. A soluble form of CD143 is likely shed from endothelial cells and is found in serum, plasma, seminal fluid, amniotic fluid and cerebral spinal fluid. Functionally, CD143 has a role in blood pressure regulation, electrolyte balance, reproduction, cardiovascular disease, kidney disease, cancer and Alzheimer’s disease. Inhibitors of ACE are used clinically to treat hypertension, cardiac failure, and diabetic retinopathy.
- Synonyms: Angiotensin I converting enzyme; CD143; testicular ECA carboxycathepsin; DCP; ACE1; DCP1; MVCD3
- CAS Number: 9007-83-4
- NCBI Gene ID: 1636
- UniProt: P12821
- Accession Number: NP_00780.1
- Accession Number mRNA: NM_000789
- Gene Location: 17q23.3
- Host: Mouse
- Origin Species: Human
- Species Reactivity: Human
- Target Antigen: Human ACE Recombinant protein (extracellular domain)
- Isotype: IgG1
- Clone: (#12J16)
- Validated Applications: WB
- Purification Method: Protein G chromatography
- Form: Lyophilized
- Buffer: PBS
- Reconstitution: Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
- Shipping Conditions: Room Temperature
- Storage Conditions: Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.