Medroxyprogesterone acetate

• Description :

  Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors[1].

• Product Name Alternative :

  Medroxyprogesterone 17-acetate; Farlutin

• UNSPSC :

  12352211

• Hazard Statement :

  H351, H413

• Target :

  Androgen Receptor; Endogenous Metabolite; Glucocorticoid Receptor; Progesterone Receptor

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Endocrinology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Medroxyprogesterone-acetate.html

• Purity :

  99.88

• Solubility :

  DMSO : 10 mg/mL (ultrasonic) |Ethanol : 6.25 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL

• Smiles :

  CC(O[C@@]([C@]12C)(CC[C@@]1([H])[C@@](C[C@H](C)C3=CC4=O)([H])[C@]([C@]3(CC4)C)([H])CC2)C(C)=O)=O

• Molecular Formula :

  C24H34O4

• Molecular Weight :

  386.52

• Precautions :

  H351, H413

• References & Citations :

  [1]Schindler AE, et al. Classification and pharmacology of progestins. Maturitas. 2008 Sep-Oct;61 (1-2) :171-80.|[2]Simoncini T, et al. Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells. Endocrinology. 2004 Dec;145 (12) :5745-56. |[3]Smith D, et al. Pharmacokinetics and bioavailability of medroxyprogesterone acetate in the dog and the rat. Biopharm Drug Dispos. 1993 May;14 (4) :341-55. |[4]Bernardi F, et al. Progesterone and medroxyprogesterone acetate effects on central and peripheral allopregnanolone and beta-endorphin levels. Neuroendocrinology. 2006;83 (5-6) :348-59.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• CAS Number :

  [71-58-9]