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Medroxyprogesterone

CAT: 0804-HY-B0648-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0648-01Size:100 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Medroxyprogesterone (17α-Hydroxy-6α-methylprogesterone) is a synthetic human variant of progesterone that is a progesterone receptor agonist with oral activity. Medroxyprogesterone can induce cell proliferation through the PI3K/Akt signaling pathway. Medroxyprogesterone has an inhibitory effect on atherosclerosis in mice. The progesterone agonist activity of Medroxyprogesterone is less effective than Medroxyprogesterone acetate (HY-B0469) [1][2][3][4].
CAS Number
[520-85-4]
Product Name Alternative
17α-Hydroxy-6α-methylprogesterone; U8840
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Progesterone Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/Medroxyprogesterone.html
Purity
98.82
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@@]1([C@@]2(O)C(C)=O)[C@](CC2)([H])[C@@](C[C@H](C)C3=CC4=O)([H])[C@]([C@]3(CC4)C)([H])CC1
Molecular Formula
C22H32O3
Molecular Weight
344.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Saitoh M, et al. Medroxyprogesterone acetate induces cell proliferation through up-regulation of cyclin D1 expression via phosphatidylinositol 3-kinase/Akt/nuclear factor-kappaB cascade in human breast cancer cells. Endocrinology. 2005 Nov;146 (11) :4917-25.|[2]Ito F, et al. Medroxyprogesterone acetate enhances monocyte-endothelial interaction under flow conditions by stimulating the expression of cell adhesion molecules. J Clin Endocrinol Metab. 2014 Jun;99 (6) :2188-97.|[3] Freudenberger T, et al. Differential effects of medroxyprogesterone acetate on thrombosis and atherosclerosis in mice. Br J Pharmacol. 2009 Dec;158 (8) :1951-60.|[4]Yusop SNW, et al. Medroxyprogesterone derivatives from microbial transformation as anti-proliferative agents and acetylcholineterase inhibitors (combined in vitro and in silico approaches) . Steroids. 2020 Dec;164:108735.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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