Picamilon

• Description :

  Picamilon is an orally active derivative of γ-aminobutyric acid that has nootropic effect. Picamilon improves the epilepsy model in rats and promotes correction of functional disorders of the pancreas during Alloxan (HY-W017227) -induced diabetes mellitus in rats[1][2][3].

• CAS Number :

  [34562-97-5]

• Product Name Alternative :

  Nicotinoyl-GABA; Nicotinoyl-γ-aminobutyric acid

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  GABA Receptor

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/picamilon.html

• Concentration :

  10mM

• Purity :

  99.37

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  OC(CCCNC(C1=CN=CC=C1)=O)=O

• Molecular Formula :

  C10H12N2O3

• Molecular Weight :

  208.22

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Mirzoian RS, et al. Vliianie pikamilona na krovosnabzhenie kory i mikrotsirkuliatsiiu v sisteme pial'nykh arteriol [Effect of pikamilon on the cortical blood supply and microcirculation in the pial arteriole system]. Biull Eksp Biol Med. 1989 May;107 (5) :581-2. Russian. |[2]Denisenko, et al. Effects of Picamilon and Isopicamilon on the Formation of Picrotoxin-Induced Convulsive Activity in Rats. Neurophysiology 46, 284–287 (2014) .

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2