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WAAG-3R (TFA)

CAT: 0804-HY-P5419A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P5419A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay[1][2]. (Ex/Em = 340/420 nm)
UNSPSC
12352209
Target
Biochemical Assay Reagents
Type
Peptides
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/waag-3r-tfa.html
Purity
99.75
Solubility
H2O : 12.5 mg/mL (ultrasonic)
Smiles
O=[N+](C1=CC([N+]([O-])=O)=CC=C1NC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC(C2=C(C=CC=C2)N)=O)[C@@H](C)O)=O)CCC(O)=O)=O)=O)CCC(O)=O)=O)C)=O)CCCNC(N)=N)=O)=O)CO)=O)C(C)C)=O)[C@H](CC)C)=O)C(N[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CCCCN)=O)[O-].OC(C(F)(F)F)=O.[x]
Molecular Formula
C69H109N23O24.xC2HF3O2
Molecular Weight
1644.74 (free base)
References & Citations
[1]De Savi C, et al. The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis[J]. Bioorganic & medicinal chemistry letters, 2011, 21 (5) : 1376-1381.|[2]Hongfeng Deng, et al. Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT) . J Med Chem. 2012 Aug 23;55 (16) :7061-79.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported

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