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MDH1-IN-2

CAT: 0804-HY-147791-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147791-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MDH1-IN-2 (Compound 7c) is a selective MDH1 inhibitor, with IC50 values of 2.27 and 27.47 μM for MDH1 and MDH2, respectively. MDH1-IN-2 can reduce the generation of ROS by inhibiting the conversion of 2-Ketoglutaric acid to α-Hydroxyglutaric acid (HY-113038B) mediated by MDH1, thereby suppressing 2-Ketoglutaric acid (HY-W013636) -induced ferroptosis[1][2].
CAS Number
2143463-35-6
UNSPSC
12352005
Target
Ferroptosis; Malate Dehydrogenase (MDH) ; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mdh1-in-2.html
Purity
98.70
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(OC)C1=CC=C(OC)C(NC(COC2=CC=C(C(C)(C)CC(C)(C)C)C=C2)=O)=C1
Molecular Formula
C25H33NO5
Molecular Weight
427.53
References & Citations
[1]Naik R, et al. Methyl 3- (3- (4- (2,4,4-Trimethylpentan-2-yl) phenoxy) -propanamido) benzoate as a Novel and Dual Malate Dehydrogenase (MDH) 1/2 Inhibitor Targeting Cancer Metabolism. J Med Chem. 2017;60 (20) :8631-8646.|[2]Cai Y, et al. α-KG inhibits tumor growth of diffuse large B-cell lymphoma by inducing ROS and TP53-mediated ferroptosis. Cell Death Discov. 2023 Jun 12;9 (1) :182.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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