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Esculin

CAT: 0804-HY-N0188-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0188-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases[1][2][3][4][5][6][7].
CAS Number
531-75-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
P38 MAPK
Type
Natural Products
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/esculin.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=CC2=CC(O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)=C(O)C=C2O1
Molecular Formula
C15H16O9
Molecular Weight
340.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Knox K, et al. The Coumarin Glucoside, Esculin, Reveals Rapid Changes in Phloem-Transport Velocity in Response to Environmental Cues. Plant Physiol. 2018 Oct;178 (2) :795-807.|[2]Song Y, et al. Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway. Mol Med Rep. 2018 May;17 (5) :7395-7402.|[3]Li CX, et al. Phytother Res. 2022 Jun;36 (6) :2434-2448.|[4]Li W, et al. Gastroprotective effect of esculin on ethanol-induced gastric lesion in mice. Fundam Clin Pharmacol. 2017 Apr;31 (2) :174-184.|[5]Arif A, et al. Esculin protects human blood cells from bioallethrin-induced toxicity: An ex vivo study. Pestic Biochem Physiol. 2023 Apr;191:105375.|[6]Shan LP, et al. Antiviral activity of esculin against white spot syndrome virus: A new starting point for prevention and control of white spot disease outbreaks in shrimp seedling culture. J Fish Dis. 2022 Jan;45 (1) :59-68.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
P38 MAPK

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