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N-Hydroxysuccinimide

CAT: 0804-HY-Y0623-01Size: 5 gDry Ice: NoHazardous: No
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CAT#:0804-HY-Y0623-01Size:5 g
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Description
N-Hydroxysuccinimide (HOSu; 1-Hydroxy-2,5-pyrrolidinedione) is a covalent crosslinker commonly used in bioconjugation technology with a primary amine group. N-Hydroxysuccinimide reacts with amino groups (-NH2) to form a stable amide bond, which can modify amino-containing biomolecules. N-Hydroxysuccinimide can be used, for example, for protein labeling with fluorescent dyes and enzymes, surface activation of chromatography supports, microbeads, nanoparticles and microarray slides, and chemical synthesis of peptides. N-Hydroxysuccinimide has a wide range of applications in biomaterial synthesis (such as collagen, chitosan crosslinking), drug delivery systems (such as hydrogel preparation) and tissue engineering[1][2][3].
CAS Number
6066-82-6
Product Name Alternative
HOSu; 1-Hydroxy-2,5-pyrrolidinedione
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
Biochemical Assay Reagents
Type
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/n-hydroxysuccinimide.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1O)CCC1=O
Molecular Formula
C4H5NO3
Molecular Weight
115.09
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang M, et al. Interactions of collagen molecules in the presence of N-hydroxysuccinimide activated adipic acid (NHS-AA) as a crosslinking agent. Int J Biol Macromol. 2011 Nov 1;49 (4) :847-54.|[2]Ishikawa S, et al. N-Hydroxysuccinimide Bifunctionalized Triblock Cross-Linker Having Hydrolysis Property for a Biodegradable and Injectable Hydrogel System. ACS Biomater Sci Eng. 2019 Nov 11;5 (11) :5759-5769.|[3]Klykov O, et al. Quantification of N-hydroxysuccinimide and N-hydroxysulfosuccinimide by hydrophilic interaction chromatography (HILIC) [J]. Analytical methods, 2015, 7 (15) : 6443-6448.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

Chemical Information

N-Hydroxysuccinimide

structure

CAS Number6066-82-6
PubChem CID80170
IUPAC Name1-hydroxypyrrolidine-2,5-dione
Molecular FormulaC4H5NO3
Molecular Weight115.09
XLogP-1.4
Topological Polar Surface Area57.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Heavy Atom Count8
Formal Charge0
Complexity126
SMILES
C1CC(=O)N(C1=O)O
InChI
InChI=1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2
InChIKey
NQTADLQHYWFPDB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-Hydroxysuccinimide
CAS: 6066-82-6
CID: 80170
Formula: C4H5NO3
MW: 115.09
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight115.09
XLogP3-1.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass115.026943022
Monoisotopic Mass115.026943022
Topological Polar Surface Area57.6 Ų
Heavy Atom Count8
Formal Charge0
Complexity126
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
4025878.0100N-Hydroxysuccinimide
708007N‐HYDROXYSUCCINIMIDE

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