Etoposide-13C,d3

Etoposide-13C,d3

• UNSPSC Description: Etoposide-13C,d3 is the 13C- and deuterium labeled Etoposide. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy[1].
• Target Antigen: Antibiotic; Apoptosis; Autophagy; Bacterial; Isotope-Labeled Compounds; Mitophagy; Topoisomerase
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Apoptosis;Autophagy;Cell Cycle/DNA Damage;Others
• Field of Research: Cancer; Infection
• Smiles: C[C@@H]1OC[C@]2([H])[C@@]([C@H](O)[C@@H](O)[C@H](O[C@@H]3C(C=C(OCO4)C4=C5)=C5[C@@H](C6=CC(OC)=C(O)C(O[13C]([2H])([2H])[2H])=C6)[C@]7([H])[C@]3([H])COC7=O)O2)([H])O1
• Molecular Weight: 592.57
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.|[2]Calvani M, det al. Etoposide-Anti-Human VEGF a new strategy against human melanoma cells expressing stem-like traits. Oncotarget. 2016 Jun 9. doi: 10.18632/oncotarget.9939.|[3]Cui D, et al. FBXW7 Confers Radiation Survival by Targeting p53 for Degradation.Cell Rep. 2020 Jan 14;30(2):497-509.e4.|[4]Fuchs, J., et al. Comparative activity of NSC 119875, NSC 109724, NSC 123127, NSC 241240, and etoposide in heterotransplanted hepatoblastoma. Cancer, 1998. 83(11): p. 2400-7.|[5]Hande KR, et al. The Importance of Drug Scheduling in Cancer Chemotherapy: Etoposide as an Example. Oncologist. 1996;1(4):234-239.|[6]Lee KI, et al. Etoposide induces pancreatic β-cells cytotoxicity via the JNK/ERK/GSK-3 signaling-mediated mitochondria-dependent apoptosis pathway. Toxicol In Vitro. 2016 Jul 26. pii: S0887-2333(16)30147-3.
• Shipping Conditions: Room Temperature