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DRP1 Polyclonal Antibody

CAT: 0763-D-AB-10190L-01Size: 25 µLDry Ice: NoHazardous: No
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CAT#:0763-D-AB-10190L-01Size:25 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF) . Alternative splicing results in multiple transcript variants encoding different isoforms.
Abbreviation
DRP1
UniProt
O00429
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human DNM1L protein expressed by E.coli
Target
DLP1; dnm1l; DNM1L; Dnm1p/Vps1p-like protein; dnml1; DRP1; DVLP; Dymple; Dynamin 1 like; Dynamin family member proline-rich carboxyl-terminal domain less; Dynamin like protein; Dynamin related protein 1; Dynamin-1-like protein; Dynamin-like protein 4; Dynamin-like protein; Dynamin-like protein IV; Dynamin-related protein 1; DYNIV 11; EMPF; EMPF1; FLJ41912; HdynIV; VPS1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IF
Field of Research
Cancer; Cell Biology; Metabolism; Neuroscience; Signal Transduction
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IF 1:50-1:200
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
82kDa
Observed Molecular Weight
82kDa
Isotype
IgG

UniProtKB · O00429

Dynamin-1-like protein

DNM1L_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O00429
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DNM1L
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.6.5.5
Processing
—
Secondary accessions
A8K4X9, B4DGC9, B4DSU8, G8JLD5, J3KPI2, O14541, O60709, Q59GN9, Q7L6B3, Q8TBT7, Q9BWM1, Q9Y5J2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationGlycoproteinIsopeptide bondPhosphoproteinS-nitrosylationUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

Biological rhythmsEndocytosisNecrosis

Cellular component

Coated pitCytoplasmCytoplasmic vesicleGolgi apparatusMembraneMitochondrionMitochondrion outer membranePeroxisomeSynapse

Disease

Disease variant

Ligand

GTP-bindingLipid-bindingNucleotide-binding

Molecular function

Hydrolase
Product Datasheet
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