NCGC00249987

CAT: 0804-HY-133512-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-133512-01Size:5 mg

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Description

NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of Eya2 inhibitor with IC50s of 3 μM and 6.9 μM for Eya2 ED and MBP-Eya2 FL. NCGC00249987 specifically targets migration, invadopodia formation, and invasion of lung cancer cells[1].

CAS Number

1384864-80-5

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ncgc00249987.html

Purity

99.58

Solubility

DMSO : < 1 mg/mL

Smiles

FC1=CC=CC(C(N/N=C/C(O2)=CC=C2SC3=NC=CC=N3)=O)=C1

Molecular Formula

C16H11FN4O2S

Molecular Weight

342.35

References & Citations

[1]Anantharajan J, et al. Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells. Mol Cancer Ther. 2019 Sep;18 (9) :1484-1496.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Catalog	Name
BA8104-5	NCGC00249987

NCGC00249987

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