11 ß-HSD1 HDR Plasmid

• Description:

  11 ß-HSD1 HDR Plasmid_x000D_ Catalog number: B2015173_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 10 ¬µg_x000D_ Molecular Weight or Concentration: N/A_x000D_ Supplied as: Powder_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: 2 - 8 ¬∞C_x000D_ Keywords: 11 ß-HSD1 HDR Plasmid_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Odermatt A, Nashev LG. The glucocorticoid-activating enzyme 11beta-hydroxysteroid dehydrogenase type 1 has broad substrate specificity: Physiological and toxicological considerations J Steroid Biochem Mol Biol. 2010 Mar;119(1-2):1-13._x000D_ 2: Burns DM, He C, Li YL, Zhuo J, Qian DQ, Chen L, Jalluri R, Diamond S, Covington MB, Li Y, Wynn R, Scherle P, Yeleswaram S, Hollis G, Friedman S, Metcalf B, Yao W. Discovery of a novel 2-spiroproline steroid mimetic scaffold for the potent inhibition of 11 ß-HSD1 Bioorg Med Chem Lett. 2022 Oct 1;73:128884._x000D_ 3: Hassan-Smith ZK, Morgan SA, Sherlock M, Hughes B, Taylor AE, Lavery GG, Tomlinson JW, Stewart PM. Gender-Specific Differences in Skeletal Muscle 11 ß-HSD1 Expression Across Healthy Aging J Clin Endocrinol Metab. 2015 Jul;100(7):2673-81._x000D_ 4: Harno E, Cottrell EC, Yu A, DeSchoolmeester J, Gutierrez PM, Denn M, Swales JG, Goldberg FW, Bohlooly-Y M, Anders√©n H, Wild MJ, Turnbull AV, Leighton B, White A. 11 ß-Hydroxysteroid dehydrogenase type 1 (11 ß-HSD1) inhibitors still improve metabolic phenotype in male 11 ß-HSD1 knockout mice suggesting off-target mechanisms Endocrinology. 2013 Dec;154(12):4580-93._x000D_ 5: Cooper MS, Stewart PM. 11Beta-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation J Clin Endocrinol Metab. 2009 Dec;94(12):4645-54._x000D_ 6: Li F, Zhou C, Gao M, Xu L, Wen G, Zhao J, Yan J. Effect of 11 ß-HSD1 inhibitor on bone microstructure and bone density in rats with femoral head necrosis J Musculoskelet Neuronal Interact. 2020 Jun 1;20(2):282-290._x000D_ 7: Konstantakou P, Mastorakos G, Vrachnis N, Tomlinson JW, Valsamakis G. Dysregulation of 11beta-hydroxysteroid dehydrogenases: implications during pregnancy and beyond J Matern Fetal Neonatal Med. 2017 Feb;30(3):284-293._x000D_ 8: Wang GC, Yu JH, Shen Y, Leng Y, Zhang H, Yue JM. Limonoids and Triterpenoids as 11 ß-HSD1 Inhibitors from Walsura robusta J Nat Prod. 2016 Apr 22;79(4):899-906._x000D_ 9: F√ºrst-Recktenwald S, D√∂rr HG, Quinkler M, D√∂tsch J, Stewart PM. Is there sufficient evidence to consider the use of 11 ß-hydroxysteroid dehydrogenase type 1 inhibition in children? Clin Endocrinol (Oxf). 2012 Aug;77(2):159-68._x000D_ 10: Dodd S, Skvarc DR, Dean OM, Anderson A, Kotowicz M, Berk M. Effect of Glucocorticoid and 11 ß-Hydroxysteroid-Dehydrogenase Type 1 (11 ß-HSD1) in Neurological and Psychiatric Disorders Int J Neuropsychopharmacol. 2022 May 27;25(5):387-398. _x000D_ _x000D_ Products Related to 11 ß-HSD1 HDR Plasmid can be found at DNA

• Short Description:

  Catalog Number: B2015173 (10 µg)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height:

  0.5

• Height :

  0.5