DMTr-LNA-C(Bz)-3-CED-phosphoramidite

DMTr-LNA-C(Bz)-3-CED-phosphoramidite

• CAS Number: 206055-78-9
• UNSPSC Description: DMTr-LNA-C(Bz)-3-CED-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dmtr-lna-c-bz-3-ced-phosphoramidite.html
• Solubility: 10 mM in DMSO
• Smiles: [H][C@@]12[C@H](N3C(N=C(NC(C4=CC=CC=C4)=O)C=C3)=O)O[C@@]([C@H]2OP(N(C(C)C)C(C)C)OCCC#N)(COC(C5=CC=C(OC)C=C5)(C6=CC=CC=C6)C7=CC=C(OC)C=C7)CO1
• Molecular Weight: 861.92
• References & Citations: [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported