DMTr-LNA-C(Bz)-3-CED-phosphoramidite

• UNSPSC Description:

  DMTr-LNA-C(Bz)-3-CED-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

• Target Antigen:

  Nucleoside Antimetabolite/Analog

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dmtr-lna-c-bz-3-ced-phosphoramidite.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@@]12[C@H](N3C(N=C(NC(C4=CC=CC=C4)=O)C=C3)=O)O[C@@]([C@H]2OP(N(C(C)C)C(C)C)OCCC#N)(COC(C5=CC=C(OC)C=C5)(C6=CC=CC=C6)C7=CC=C(OC)C=C7)CO1

• Molecular Weight:

  861.92

• References & Citations:

  [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  206055-78-9