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Trans-Anethole

CAT: 0804-HY-N0367-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-N0367-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Trans-Anethole ((E) -Anethole) is an orally active phenylpropene derivative found in Foeniculum vulgare that is estrogenic at low concentrations and cytotoxic at high concentrations in tumor cell lines. Trans-Anethole also has anti-aflatoxin, anti-thrombotic and anti-diabetic activities. Trans-Anethole is an important odor component in plants such as fennel, myrtle, liquorice, and camphor[1][2][3][4][5][6][7].
CAS Number
4180-23-8
Product Name Alternative
(E) ​-Anethole
UNSPSC
12352005
Hazard Statement
H317, H411
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology; Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Trans-Anethole.html
Purity
99.70
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=C(/C=C/C)C=C1
Molecular Formula
C10H12O
Molecular Weight
148.21
Precautions
H317, H411
References & Citations
[1]Tabanca N, et al. Estrogenic activity of isolated compounds and essential oils of Pimpinella species from Turkey, evaluated using a recombinant yeast screen. Planta Med. 2004 Aug;70 (8) :728-35.|[2]Nakagawa Y, et al. Cytotoxic and xenoestrogenic effects via biotransformation of trans-anethole on isolated rat hepatocytes and cultured MCF-7 human breast cancer cells. Biochem Pharmacol. 2003 Jul 1;66 (1) :63-73.|[3]Fahlbusch, et al. "Flavors and Fragrances", Ullmann's Encyclopedia of Industrial Chemistry, Weinheim: Wiley-VCH.|[4]Tognolini M, et al. Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. Pharmacological Research 2007; 56: 254-260. |[5]Sheikh, et al. Trans-anethole, a terpenoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats. Biochimie 112 (2015) : 57-65.|[6]Dhar, et al. Anti-fertility activity and hormonal profile of trans-anethole in rats. Indian journal of physiology and pharmacology 39 (1995) : 63-63.|[7]JD Lei, et al. "Antifungal effects of trans-anethole, the main constituent of Illicium verum fruit volatiles, on Aspergillus flavus in stored wheat." Food Control 149 (2023) : 109721.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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