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DMCM (hydrochloride)

CAT: 0804-HY-100369A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100369A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DMCM hydrochloride is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with Kis of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5 receptors, respectively[1].
CAS Number
1215833-62-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/DMCM-hydrochloride.html
Purity
99.07
Solubility
DMSO : 10 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)
Smiles
O=C(C1=C(CC)C2=C(C=N1)NC3=C2C=C(OC)C(OC)=C3)OC.[H]Cl
Molecular Formula
C17H19ClN2O4
Molecular Weight
350.80
Precautions
H302, H315, H319, H335
References & Citations
[1]Chambers MS, et al. An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties. J Med Chem. 2004 Nov 18;47 (24) :5829-32.|[2]Leppä E, et al. Agonistic effects of the beta-carboline DMCM revealed in GABA (A) receptor gamma 2 subunit F77I point-mutated mice. Neuropharmacology. 2005 Mar;48 (4) :469-78.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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