10074-G5

CAT: 0400-SIH-609-5MGSize: 5 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-609-5MGSize:5 mg
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AVAILABILITY: InStock
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Background
10074-G5 binds to and distorts the bHLH-ZIP domain of c-Myc, thereby inhibiting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity (1). 10074-G5 is capable of binding and sequestering the intrinsically disordered amyloid-β (Aβ) peptide in its monomeric, soluble state. Our analysis reveals that this compound interacts with Aβ and inhibits both the primary and secondary nucleation pathways in its aggregation process (2).
Description
C-Myc inhibitor
CAS Number
413611-93-5
Product Name Alternative
7-Nitro-N- (2-phenylphenyl) -2,1,3-benzoxadiazol-4-amine
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Neurodegeneration | Alzheimer's Disease | Amyloid | Tags and Cell Markers | Epitope Tags | Myc Tag
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
Orange powder
Solubility
May be dissolved in DMSO (40 mg/ml)
Molecular Formula
C18H12N4O3
Molecular Weight
332.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Follis A.V. et al. (2008) Chem. Biol. 15: 1149. 2. Heller G.T. (2020) ScienceAdvances. 6(45): DOI: 10.1126/sciadv.abb5924.

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