10074-G5

• Background:

  10074-G5 binds to and distorts the bHLH-ZIP domain of c-Myc, thereby inhibiting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity (1). 10074-G5 is capable of binding and sequestering the intrinsically disordered amyloid-β (Aβ) peptide in its monomeric, soluble state. Our analysis reveals that this compound interacts with Aβ and inhibits both the primary and secondary nucleation pathways in its aggregation process (2).

• Description:

  C-Myc inhibitor

• Product Name Alternative:

  7-Nitro-N- (2-phenylphenyl) -2,1,3-benzoxadiazol-4-amine

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Neuroscience | Neurodegeneration | Alzheimer's Disease | Amyloid | Tags and Cell Markers | Epitope Tags | Myc Tag

• Purity:

  >98% (TLC) ; NMR (Conforms)

• Weight:

  0.005

• Format:

  Orange powder

• Solubility:

  May be dissolved in DMSO (40 mg/ml)

• Molecular Formula:

  C18H12N4O3

• Molecular Weight:

  332.3

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Follis A.V. et al. (2008) Chem. Biol. 15: 1149. 2. Heller G.T. (2020) ScienceAdvances. 6(45): DOI: 10.1126/sciadv.abb5924.

• CAS Number:

  413611-93-5