TTNPB

• Background:

  TTNPB is an analog of retinoic acid that potently and selectively activates retinoic acid receptors (1). Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Tranylcypromine, Valproic Acid, 3-Deazaneplanocin A, and E-616452 (2). And it Induces the in vitro growth and differentiation to granulocytes of myeloid progenitors isolated from myelodysplastic syndrome (MDS) patients (3).

• Description:

  Retinoic acid receptor agonist

• Product Name Alternative:

  4-[ (E) -2- (5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) -1-propenyl]benzoic acid; Ro 13-7410; AGN-191183

• UNSPSC:

  41116105

• Type:

  Agonist

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis | Stem Cells

• Purity:

  >98% (HPLC) ; NMR (Conforms)

• Weight:

  0.005

• Format:

  Off-white powder

• Solubility:

  May be dissolved in DMSO (4 mg/ml)

• Molecular Formula:

  C24H28O2

• Molecular Weight:

  348.5

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Beard R.L., et al. (1995) J Med Chem. 38 (15): 2820-2829. 2. Hou P. et al. (2013) Science. 341 (6146): 651-654. 3. Fabian I. (1987) Leukemia Research. 11 (7): 635-640.

• CAS Number:

  71441-28-6