TTNPB

• Description:

  TTNPB is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC50s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively.

• Product Name Alternative:

  Ro 13-7410; Arotinoid acid; AGN191183

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335, H360

• Target:

  Apoptosis; Autophagy; RAR/RXR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/TTNPB.html

• Purity:

  99.85

• Solubility:

  DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(O)C1=CC=C(/C=C(C2=CC=C3C(C)(C)CCC(C)(C)C3=C2)\C)C=C1

• Molecular Formula:

  C24H28O2

• Molecular Weight:

  348.48

• Precautions:

  H315, H319, H335, H360

• References & Citations:

  [1]Pignatello MA, et al. Multiple factors contribute to the toxicity of the aromatic retinoid, TTNPB (Ro 13-7410) : binding affinities and disposition. Toxicol Appl Pharmacol. 1997 Feb;142 (2) :319-27.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  71441-28-6