AM 580

• Background:

  AM-580, a benzoic derivative of retinoic acid and a selective RAR-α agonist, has been shown to significantly reduce the production of Th1 cytokines but promote Th2 cytokines in human PBMCs7 and to inhibit microglial activation, thus acting beneficially in Alzheimer's disease treatment. It also is known to inhibit tumor cell proliferation and induces apoptosis.

• Description:

  Rar agonist

• Product Name Alternative:

  4-[ (5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carboxamido]benzoic acid; CD336; NSC 608001; Ro 40-6055

• UNSPSC:

  41116105

• Type:

  Agonist

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Epigenetics and Nuclear Signaling | Transcription | Neuroscience | Cancer | Oxidative Stress | Neurodegeneration | Alzheimer's Disease

• Purity:

  >98% (HPLC) NMR (Conforms)

• Weight:

  0.005

• Format:

  Off-white powder

• Solubility:

  May be dissolved in DMSO (35 mg/ml); or Ethanol (18 mg/ml)

• Molecular Formula:

  C22H25NO3

• Molecular Weight:

  351.4

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Wang O., Thome R., Rostami A., Ma C-G., Zhang G-X. (2019) Nature. 16: 727-729. 2. Bosch A., et al. (2012) Breast Cancer Res. 14(4): R121.

• CAS Number:

  102121-60-8