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BIIB129

CAT: 0804-HY-163565-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-163565-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BIIB129 is a covalent, selective, small molecule inhibitor of Bruton's tyrosine kinase (BTK) capable of penetrating the blood-brain barrier. BIIB129 inhibits the activity of BTK by covalently binding to Cys481 in BTK, thereby affecting the function of B cells and myeloid cells. BIIB129 can be used in multiple sclerosis (MS) research[1].
CAS Number
2770960-52-4
UNSPSC
12352005
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/biib129.html
Purity
99.54
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN(N=C1)C=C1C2=CN3C(C(O[C@]4(C[C@H](C4)N(C)C(C=C)=O)C)=N2)=CC=N3
Molecular Formula
C19H22N6O2
Molecular Weight
366.42
References & Citations
[1]Himmelbauer M K, et al. Discovery and Preclinical Characterization of BIIB129, a Covalent, Selective, and Brain-Penetrant BTK Inhibitor for the Treatment of Multiple Sclerosis[J]. Journal of Medicinal Chemistry, 2024.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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