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BC-1382

CAT: 0804-HY-W062696-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W062696-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction (IC50≈ 5 nM) .Anti-inflammatory activity[1].
CAS Number
1013753-99-5
UNSPSC
12352005
Hazard Statement
H302-H312-H315-H319-H332-H335
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bc-1382.html
Purity
99.53
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1CCN(S(=O)(C2=CC=CC=C2)=O)CC1)N[C@@H](C)C(NCC3=CC=CC=C3OC)=O
Molecular Formula
C23H29N3O5S
Molecular Weight
459.56
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
References & Citations
[1]Tiffany A Coon, et al. The proinflammatory role of HECTD2 in innate immunity and experimental lung injury. Sci Transl Med. 2015 Jul 8;7 (295) :295ra109.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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