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Foropafant

CAT: 0804-HY-128694-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128694-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1].
CAS Number
136468-36-5
Product Name Alternative
SR27417
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Platelet-activating Factor Receptor (PAFR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/foropafant.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)C1=CC(C(C)C)=C(C2=CSC(=N2)N(CCN(C)C)CC2=CC=CN=C2)C(=C1)C(C)C
Molecular Formula
C28H40N4S
Molecular Weight
464.72
Precautions
H302, H315, H319, H335
References & Citations
[1]Herbert JM, et al. Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther. 1991 Oct;259 (1) :44-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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