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Caylin-1

CAT: 0804-HY-120520-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120520-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Caylin-1 is an inhibitor of MDM2 and an analog of Nutlin-3. Caylin-1 can bind to Bcl-XL and is used in multi-target anticancer research[1][2].
CAS Number
1207480-88-3
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/caylin-1.html
Solubility
10 mM in DMSO
Smiles
O=C1NCCN(C(N2[C@@H](C3=CC=C(Cl)C(Cl)=C3)[C@@H](C4=CC=C(Cl)C(Cl)=C4)N=C2C5=CC=C(OC)C=C5OC(C)C)=O)C1
Molecular Formula
C30H28Cl4N4O4
Molecular Weight
650.38
References & Citations
[1]Shin J S, et al. Structural insights into the dual-targeting mechanism of Nutlin-3[J]. Biochemical and Biophysical Research Communications, 2012, 420 (1) : 48-53.|[2]Li J, et al. A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53–MDM2 interaction[J]. Journal of biomolecular screening, 2011, 16 (4) : 450-456.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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