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Inecalcitol

CAT: 0804-HY-32344-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-32344-01Size:5 mg
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Description
Inecalcitol (TX 522), a unique vitamin D3 analog, is an orally active vitamin D receptor (VDR) agonist with a Kd of 0.53 nM. Inecalcitol can induce cell apoptosis and has potent anticancer activities[1][2][3][4]. Inecalcitol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
163217-09-2
Product Name Alternative
TX 522
UNSPSC
12352211
Target
Apoptosis; VD/VDR
Type
Reference compound
Related Pathways
Apoptosis; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/inecalcitol.html
Purity
98.11
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1C[C@H](O)C/C(C1)=C/C=C2[C@@]3([H])CC[C@H]([C@H](C)CC#CC(C)(O)C)[C@@]3(C)CCC/2
Molecular Formula
C26H40O3
Molecular Weight
400.59
References & Citations
[1]Ryoko Okamoto, et al. Inecalcitol, an analog of 1α,25 (OH) (2) D (3), induces growth arrest of androgen-dependent prostate cancer cells. Int J Cancer. 2012 May 15;130 (10) :2464-73.|[2]Jacques Medioni, et al. Phase I safety and pharmacodynamic of inecalcitol, a novel VDR agonist with docetaxel in metastatic castration-resistant prostate cancer patients. Clin Cancer Res. 2014 Sep 1;20 (17) :4471-7.|[3]Yingyu Ma, et al. Inecalcitol, an analog of 1,25D3, displays enhanced antitumor activity through the induction of apoptosis in a squamous cell carcinoma model system. Cell Cycle. 2013 Mar 1;12 (5) :743-52.|[4]L Verlinden, et al. Interaction of two novel 14-epivitamin D3 analogs with vitamin D3 receptor-retinoid X receptor heterodimers on vitamin D3 responsive elements. J Bone Miner Res. 2001 Apr;16 (4) :625-38.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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