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AF12198

CAT: 0804-HY-P1110-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1110-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8 nM) but not the human type II receptor (IC50=6.7 µM) or the murine type I receptor (IC50>200 µM) . AF12198 inhibits IL-1-induced IL-8 production (IC50=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC50=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo[1].
CAS Number
185413-30-3
UNSPSC
12352209
Target
Interleukin Related
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/af12198.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](CCC1)C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N2[C@@H](CC2)C(N[C@H](C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N[C@H](C(N)=O)CC(C)C)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)CC5=CC=C(C=C5)O)=O)CC6=CNC7=CC=CC=C67)=O)=O)[C@H]([C@H](O)C)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC8=CC=CC=C8)=O)=O)CC9=CNC%10=CC=CC=C9%10)=O
Molecular Formula
C96H123N19O22
Molecular Weight
1895.12
References & Citations
[1]F Aimbire, et al. Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL-1beta levels in airway and lung from rat subjected to LPS-induced inflammation. Inflammation|[2]A L Akeson, et al.AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL) -1 receptor and blocks in vivo responses to IL-1. J Biol Chem. 1996 Nov 29;271 (48) :30517-23.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
IL-1; IL-6; IL-8

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