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4-Aminonaphthalimide

CAT: 0804-HY-15276-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15276-01Size:5 mg
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Description
4-Aminonaphthalimide is a potent PARP inhibitor and potentiates the cytotoxicity of γ-radiation in cancer cells[1].
CAS Number
1742-95-6
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-aminonaphthalimide.html
Purity
97.0
Solubility
DMSO : 1 mg/mL (ultrasonic; warming)
Smiles
O=C1NC(C2=CC=C(N)C3=CC=CC1=C23)=O
Molecular Formula
C12H8N2O2
Molecular Weight
212.21
Precautions
H315, H319, H335
References & Citations
[1]Schlicker A, et al. 4-Amino-1,8-naphthalimide: a novel inhibitor of poly (ADP-ribose) polymerase and radiation sensitizer. Int J Radiat Biol. 1999 Jan;75 (1) :91-100.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

4-Amino-1,8-naphthalimide

4-amino-1,8-naphthalimide is a dicarboximide and a benzoisoquinoline.

CAS Number1742-95-6
PubChem CID1720
IUPAC Name6-aminobenzo[de]isoquinoline-1,3-dione
Molecular FormulaC12H8N2O2
Molecular Weight212.20
XLogP1.3
Topological Polar Surface Area72.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Heavy Atom Count16
Formal Charge0
Complexity342
SMILES
C1=CC2=C(C=CC3=C2C(=C1)C(=O)NC3=O)N
InChI
InChI=1S/C12H8N2O2/c13-9-5-4-8-10-6(9)2-1-3-7(10)11(15)14-12(8)16/h1-5H,13H2,(H,14,15,16)
InChIKey
SSMIFVHARFVINF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-Amino-1,8-naphthalimide
CAS: 1742-95-6
CID: 1720
Formula: C12H8N2O2
MW: 212.20
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight212.20
XLogP31.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass212.058577502
Monoisotopic Mass212.058577502
Topological Polar Surface Area72.2 Ų
Heavy Atom Count16
Formal Charge0
Complexity342
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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