Products for Research Use Only
RegisterLogin

Resatorvid

CAT: 0804-HY-11109-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-11109-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases[1][2].
CAS Number
243984-11-4
Product Name Alternative
TAK-242; CLI-095
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Interleukin Related; TNF Receptor; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/TAK-242.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 20 mg/mL (ultrasonic; warming)
Smiles
O=S([C@H]1C(C(OCC)=O)=CCCC1)(NC2=CC=C(C=C2Cl)F)=O
Molecular Formula
C15H17ClFNO4S
Molecular Weight
361.82
Precautions
H302, H315, H319, H335
References & Citations
[1]Ii M, et al. A novel cyclohexene derivative, ethyl (6R) -6-[N- (2-Chloro-4-fluorophenyl) sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.|[2]Yamada M, et al. Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6- (N-substituted sulfamoyl) cyclohex-1-ene-1-carboxylate. J Med Chem. 2005 Nov 17;48 (23) :7457-67.|[3]Yuko Ono, et al. TAK-242, a Specific Inhibitor of Toll-like Receptor 4 Signalling, Prevents Endotoxemia-Induced Skeletal Muscle Wasting in Mice. Sci Rep. 2020 Jan 20;10 (1) :694.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
IL-6; TLR4

Chemical Information

Resatorvid

Resatorvid is an investigational compound designed for the treatment of severe sepsis.

CAS Number243984-11-4
PubChem CID11703255
IUPAC Nameethyl (6R)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohexene-1-carboxylate
Molecular FormulaC15H17ClFNO4S
Molecular Weight361.8
XLogP3
Topological Polar Surface Area80.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count23
Formal Charge0
Complexity560
SMILES
CCOC(=O)C1=CCCC[C@H]1S(=O)(=O)NC2=C(C=C(C=C2)F)Cl
InChI
InChI=1S/C15H17ClFNO4S/c1-2-22-15(19)11-5-3-4-6-14(11)23(20,21)18-13-8-7-10(17)9-12(13)16/h5,7-9,14,18H,2-4,6H2,1H3/t14-/m1/s1
InChIKey
LEEIJTHMHDMWLJ-CQSZACIVSA-N
Chemical Structure
2D Structure
2D structure of Resatorvid
CAS: 243984-11-4
CID: 11703255
Formula: C15H17ClFNO4S
MW: 361.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight361.8
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass361.0550851
Monoisotopic Mass361.0550851
Topological Polar Surface Area80.9 Ų
Heavy Atom Count23
Formal Charge0
Complexity560
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3612777-01Resatorvid
A11543-5Resatorvid 5mg
A11543-25Resatorvid 25mg
A11543-2Resatorvid 2mg
A11543-1Resatorvid 1mg
A11543-100Resatorvid 100mg
A11543-50Resatorvid 50mg
A11543-10Resatorvid 10mg
S7455-5mgResatorvid (TAK-242)
MBS130179-01TAK-242(Resatorvid)

Popular Products