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Resatorvid

CAT: 0804-HY-11109-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-11109-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases[1][2].
CAS Number
243984-11-4
Product Name Alternative
TAK-242; CLI-095
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Interleukin Related; TNF Receptor; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/TAK-242.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 20 mg/mL (ultrasonic; warming)
Smiles
O=S([C@H]1C(C(OCC)=O)=CCCC1)(NC2=CC=C(C=C2Cl)F)=O
Molecular Formula
C15H17ClFNO4S
Molecular Weight
361.82
Precautions
H302, H315, H319, H335
References & Citations
[1]Ii M, et al. A novel cyclohexene derivative, ethyl (6R) -6-[N- (2-Chloro-4-fluorophenyl) sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.|[2]Yamada M, et al. Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6- (N-substituted sulfamoyl) cyclohex-1-ene-1-carboxylate. J Med Chem. 2005 Nov 17;48 (23) :7457-67.|[3]Yuko Ono, et al. TAK-242, a Specific Inhibitor of Toll-like Receptor 4 Signalling, Prevents Endotoxemia-Induced Skeletal Muscle Wasting in Mice. Sci Rep. 2020 Jan 20;10 (1) :694.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
IL-6; TLR4

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