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Anti-BCL6 APC

CAT: 0270-1A-867-T100Size: 100 TestsDry Ice: NoHazardous: No
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CAT#:0270-1A-867-T100Size:100 Tests
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BCL6 is a zinc finger-containing transcription factor, which acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. On B cells, BCL6 induces proliferation, antibody class switching and affinity maturation, whereas it inhibits their differentiation into plasma cells. On T cells, BCL6 induces their differentiation into T-FH cells.
Certification
RUO
Reactivity
Mouse, Human
Immunogen
PCDNA3 plasmid containing full-length sequence of human BCL6
Target Antigen
BCL6
Clone
IG191E/A8
Applications
FC-IC (QC tested)
Format
APC
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Jain S, Stock A, Macian F, Putterman C: A Distinct T follicular helper cell subset infiltrates the brain in murine neuropsychiatric lupus. Front Immunol. 2018 Mar 13;9:487., URL: https://pubmed.ncbi.nlm.nih.gov/29593732/, *Hoser D, Schön C, Loddenkemper C, Lohneis P, Kühl AA, Sommermann T, Blankenstein T, Willimsky G: Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice. Blood. 2018 Aug 30;132 (9) :924-934., URL: https://pubmed.ncbi.nlm.nih.gov/30002144/, *Tan HX, Esterbauer R, Vanderven HA, Juno JA, Kent SJ, Wheatley AK: Inducible Bronchus-Associated Lymphoid Tissues (iBALT) Serve as Sites of B Cell Selection and Maturation Following Influenza Infection in Mice. Front Immunol. 2019 Mar 29;10:611., URL: https://www.ncbi.nlm.nih.gov/pubmed/30984186, *Jiang W, Wragg KM, Tan HX, Kelly HG, Wheatley AK, Kent SJ, Juno JA: Identification of murine antigen-specific T follicular helper cells using an activation-induced marker assay. J Immunol Methods. 2019 Apr;467:48-57., URL: https://pubmed.ncbi.nlm.nih.gov/30802449/
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody IG191E/A8 recognizes BCL6, a transcriptional repressor serving as a master regulator of germinal center reaction.
Applications Notes
6
Isotype
Mouse IgG1

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