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FEN1 Protein

CAT: 0247-OPPA02024-5UGSize: 5 µgDry Ice: NoHazardous: No
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CAT#:0247-OPPA02024-5UGSize:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Aliases
MF1, RAD2, FEN-1
Gene ID
2237
Accession Number
NP_004102.1
Reactivity
Human
Target
FEN1 removes 5'' overhanging flaps in DNA repair and processes the 5'' ends of Okazaki fragments in lagging strand DNA synthesis. The interaction between FEN1 and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, therefore passing the substrate from one enzyme to another. FEN1 is part of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5'' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
Type
Protein
Source
E. coli
Purification
The FEN1 protein is purified by standard chromatogrpahy techniques.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
Varies by lot. See vial for concentration.
Format
Liquid.//20mM Tris-HCl buffer pH-8.0, 1mM DTT, 10% glycerol. Physical Appearance: //Sterile filtered colorless solution.Physical Appearance: //Sterile filtered colorless solution.
Reconstitution
Avoid multiple freeze-thaw cycles. //
Molecular Weight
43 kDa
Notes
Formerly GWB-C35B67
Protein Length
Recombinant
NCBI Gene Symbol
FEN1
Protein Name
Flap endonuclease 1
Gene Name URL
FEN1

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