Products for Research Use Only
RegisterLogin

PIN1 Protein

CAT: 0247-OPPA00850-5UGSize: 5 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0247-OPPA00850-5UGSize:5 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Gene Aliases
DOD, UBL5
Gene ID
5300
Accession Number
NP_006212.1
Reactivity
Human
Target
Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA, PLK I, Wee, and Myt1 kinases), several transcription factors like b-Catenin, c-Jun, and the tumor suppressor protein p53, and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1.
Type
Protein
Sequence
MADEEKLPPG WEKRMSRSSG RVYYFNHITN ASQWERPSGN SSSGGKNGQG EPARVRCSHL LVKHSQSRRP SSWRQEKITR TKEEALELIN GYIQKIKSGE EDFESLASQF SDCSSAKARG DLGAFSRGQM QKPFEDASFA LRTGEMSGPV FTDSGIHIIL RTE.
Purification
Purified by proprietary chromatographic techniques.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Bioactivity
Specific activity is > 330 nmoles/min/mg, and is defined as the amount of enzyme that cleave 1umole of suc-AAFP-pNA per minute at 25° C in Tris-Hcl pH8.0 using chymotrypsin.
Format
Liquid// 20mM Tris-HCl buffer (pH7.5) 0.1M NaCl, 5mM DTT & 20% Glycerol.
Reconstitution
Store at 4° C if entire vial will be used within 2-4 weeks. Store, frozen at -20° C for longer periods of time. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA) . Avoid multiple freeze-thaw cycles.
Molecular Weight
18 kDa
Notes
Formerly GWB-5EC1EA
Protein Length
Recombinant
NCBI Gene Symbol
PIN1
Host or Source
E. Coli
Protein Name
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Gene Name URL
PIN1

Related Products

CatalogName
OPCD06192-50UGPIN1 Recombinant Protein
OPCD06191-50UGPIN1 Recombinant Protein
OPCD06192-200UGPIN1 Recombinant Protein
OPCD06191-200UGPIN1 Recombinant Protein
OPCD06191-10UGPIN1 Recombinant Protein
OPCD06192-10UGPIN1 Recombinant Protein
OAAB17724-400ULPIN1 Antibody
OAAN00725-200ULPIN1 Antibody
OAAJ03179-100ULPIN1 Antibody
OAEB01153-100UGPIN1 Antibody

Alternative Products

CatalogName
P517561PIN1/Rotamase Pin1 Protein (Human)
PKSH031710Recombinant Human PIN1/Rotamase Pin1 Protein
MBS2546362-01Recombinant Human PIN1 / Rotamase Pin1 Protein
SA6039XPIN1 Human Protein
GTR18983475-01Human PIN1 Protein
P517562PIN1/Rotamase Pin1 Protein (N-His, Human)
32-2671-20PIN1 Recombinant Protein
GTR18983474-01Mouse PIN1 Protein
E53A08209Recombinant Human PIN1 / Rotamase Pin1 Protein (His tag)
PKSH031711Recombinant Human PIN1/Rotamase Pin1 Protein (His Tag)

Popular Products