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GPBB Protein

CAT: 0247-OPPA00804-5UGSize: 5 µgDry Ice: NoHazardous: No
CAT#:0247-OPPA00804-5UGSize:5 µg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Aliases
GPBB
Gene ID
5834
Accession Number
NP_002853.2
Reactivity
Human
Target
Glycogen phosphorylase is one of the phosphorylaseenzymes (EC2.4.1.1) . It breaks up glycogeninto glucosesubunits. Glycogenis left with one less glucosemolecule, and the free glucosemolecule is in the form of glucose-1-phosphate. In order to be used for metabolism, it must be converted to glucose-6-phosphateby the enzyme phosphoglucomutase._x005F Glycogen phosphorylase can only act on linearchainsof glycogen (a 1-4 glycosidic linkage) . Its work will immediately come to a halt four residues away from a 1-6 branch (which are exceedingly common in glycogen) . In these situations, a debranching enzymeis necessary, which will straighten out the chain in that area. Additionally, an alpha 1-6 glucosidaseenzymeis required to break the remaining 1-6 residue that remains in the new linear chain. After all this is done, glycogen phosphorylase can continue._x005F An insulinstimulated enzyme known as phosphoprotein phosphatase (PP-1) inactivates glycogen phosphorylase to prevent glycogen break up._x005F GPBB - a sensitive marker for the AMI diagnosis within 4 hours after the onset of chest pain. It has also been shown that GPBB is increased in a considerable proportion of AMI patients within 2-3 hours from chest pain onset. GPBB is increased early in patients with unstable angina. GPBB can also be a sensitive marker for the detection of peri-operative myocardial ischaemia and infarction in patients undergoing coronary artery bypass grafting.
Type
Protein
Source
Escherichia Coli
Applications
IA, WB
Purification
The GPBB is purified by proprietary chromatographic techniques.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid.// Each mg of protein contains 50% glycerol. Physical appearance:// Sterile Filtered colourless liquid formualtion.Physical appearance:// Sterile Filtered colourless liquid formualtion.
Molecular Weight
96695.96 Dalton
Notes
Formerly GWB-D3A389
Protein Length
Recombinant
NCBI Gene Symbol
GPBB
Protein Name
Glycogen phosphorylase, brain form
Gene Name URL
GPBB

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