DDB2 Recombinant Protein

CAT: 0247-OPCD02685-50UGSize: 50 µgDry Ice: NoHazardous: No
CAT#:0247-OPCD02685-50UGSize:50 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
9000-83-3
Gene Name
Damage specific DNA binding protein 2
Gene Aliases
Damage-specific DNA binding protein 2, 48kDa; Damage-specific DNA-binding protein 2; DDB p48 subunit; DDBB; DNA damage-binding protein 2; UV-damaged DNA-binding protein 2; UV-DDB 2; UV-DDB2; xeroderma pigmentosum group E protein; XPE.
Gene ID
1643
Accession Number
NP_000098.1
Reactivity
Homo sapiens|Human
Target
Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex) . The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1) . The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.
Conjugation
Unconjugated
Type
Protein
Source
E.coli
Applications
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
200 ug/mL (prior to lyoph)
Format
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Reconstitution
2°C to 8°C|-80°C
Molecular Weight
28kDa
Protein Length
Recombinant
NCBI Gene Symbol
DDB2
Host or Source
E.coli
Protein Name
DNA damage-binding protein 2
Gene Name URL
DDB2
Nucleotide Accession Number
NM_000107.2

Related Products

CatalogName
OCOA17554-20UGDDB2 Protein Lysate
OAAN00570-200ULDDB2 Antibody
OAAN00570-100ULDDB2 Antibody
OACD02996-1MLDDB2 Antibody
OAAN00570-50ULDDB2 Antibody
OACD02997-1MLDDB2 Antibody
OACD02996-100ULDDB2 Antibody
OACD02997-100ULDDB2 Antibody
OAAJ07132-100ULDDB2 Antibody
OACA12547-100ULDDB2 Recombinant Antibody [24E5] (OACA12547)

Alternative Products

CatalogName
RP008902DDB2 Recombinant Protein (Human)
MBS1562118-01Recombinant Human DDB2 protein
RP128267DDB2 Recombinant Protein (Mouse)
PPT-12211Human DDB2 Recombinant Protein
NBP2-38854PEPXPE/DDB2 Recombinant Protein Antigen
E45H30385E1DDB2 (NM_000107) Human Recombinant Protein
AP92649Recombinant Human DDB2 Protein, N-His
H00001643-Q01-10ugRecombinant Human XPE/DDB2 Protein - (Dry Ice)
MBS2030387-01Recombinant Damage Specific DNA Binding Protein 2 (DDB2)
MBS1282455-01Recombinant Human DNA damage-binding protein 2 (DDB2)

Popular Products