MAPK9 Recombinant Protein (Human)

CAT: 0247-OPCA03900-20UGSize: 20 µgDry Ice: NoHazardous: No
CAT#:0247-OPCA03900-20UGSize:20 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
9000-83-3
Gene Name
Mitogen-activated protein kinase 9
Gene Aliases
C-Jun kinase 2; c-Jun N-terminal kinase 2; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; JNK-55; Jun kinase; MAP kinase 9; MAPK 9; mitogen-activated protein kinase 9; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a; stress-activated protein kinase 1a; stress-activated protein kinase JNK2.
Gene ID
5601
Accession Number
NP_001128516
Reactivity
Homo sapiens|Human
Target
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692) . Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (By similarity) .
Type
Protein
Source
E.coli
Sequence
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid or Lyophilized powder
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
-20°C or -80°C
Molecular Weight
64.1 kDa
Protein Length
Recombinant
NCBI Gene Symbol
MAPK9
Protein Name
Mitogen-activated protein kinase 9
Gene Name URL
MAPK9
Nucleotide Accession Number
NM_001135044

Related Products

CatalogName
OPCD05129-10UGMAPK9 Recombinant Protein
OPCD05129-50UGMAPK9 Recombinant Protein
OPCD05129-200UGMAPK9 Recombinant Protein
OCOA06372-20UGMAPK9 Protein Lysate
OCOA00877-20UGMAPK9 Protein Lysate
OCOA06370-20UGMAPK9 Protein Lysate
OCOA06371-20UGMAPK9 Protein Lysate
OKCD08503-96WMAPK9 ELISA Kit (Human)
OAAJ06856-100ULMAPK9 Antibody
OAAJ04495-100ULMAPK9 Antibody

Alternative Products

CatalogName
E30P00390ARecombinant Human MAPK9 Protein
RP018805MAPK9 Recombinant Protein (Human)
PPT-13800Human MAPK9 Recombinant Protein
32-3056-20MAPK9 Recombinant Protein
P5215-01Recombinant Human MAPK9
ATGP1649-020Recombinant human JNK2/MAPK9 protein
RP149378MAPK9 Recombinant Protein (Mouse)
RP210833MAPK9 Recombinant Protein (Rat)
TP312273MJNK2 (MAPK9) (NM_139070) Human Recombinant Protein
PH38421M5JNK2 (MAPK9) (NM_139068) Human Recombinant Protein

Popular Products