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Ripk3 Recombinant Protein

CAT: 0247-OPCA03079-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0247-OPCA03079-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9000-83-3
Gene Name
Receptor-interacting serine-threonine kinase 3
Gene Aliases
2610528K09Rik; AW107945; mRIP3; R; receptor interacting protein 3; Receptor-interacting protein 3; receptor-interacting serine/threonine-protein kinase 3; Rip3; RIP-3; RIP-like protein kinase 3.
Gene ID
56532
Accession Number
NP_064339.2
Reactivity
Mouse|Mus musculus
Target
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Type
Protein
Source
Yeast
Purification
Affinity purified using IMAC
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
Varies by lot. See vial for concentration.
Format
Liquid// 20mM Tris-HCl, 0.5M NaCl (pH 8.0), 50% glycerol
Reconstitution
Store at -20° C; for extended storage, conserve at -20° C or -80° C. Store at 4° C for up to one week. Repeated freeze/thaw cycles are not recommended.
Molecular Weight
55 kDa
Protein Length
1-486aa
NCBI Gene Symbol
Ripk3
Protein Name
Receptor-interacting serine/threonine-protein kinase 3
Gene Name URL
Ripk3
Nucleotide Accession Number
NM_019955.2

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