L-741671

CAT: 0804-HY-119095Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-119095Size:1 Each

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Description

L-741671 is a selective and brain-permeable antagonist of neurokininl (hNKI) receptor, with Kis of 64 nM, 0.03 nM and 0.7 nM in rat, human and ferret, respectively[1].

CAS Number

187724-85-2

UNSPSC

12352005

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-741671.html

Smiles

O=C1NNC(CN2[C@@H]([C@@H](CCC2)OCC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C4=CC=CC=C4)=N1

Molecular Formula

C23H22F6N4O2

Molecular Weight

500.44

References & Citations

[1]F D Tattersall, et al. Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. Neuropharmacology. 1996;35 (8) :1121-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NK1R

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L-741671

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