MMs02943764

CAT: 0804-HY-158968-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-158968-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MMs02943764 is a 1,2,4-triazole derivative with anticancer activity. MMs02943764 has significant antiproliferative effects on multiple cancer cell lines. PAC, a structural analog of MMs02943764, has significant cytotoxicity against the leukemia cell line K562 (IC50=35.264 μM), reduces the degradation of p53 by inhibiting Mdm2 and Pirh2, and induces K562 cell cycle arrest[1].

CAS Number

708287-29-0

UNSPSC

12352005

Target

MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mms02943764.html

Purity

98.0

Smiles

O=C(CSC1=NN=C(COC2=CC(C)=CC=C2C(C)C)N1CC=C)NC3=C(Br)C=C(F)C=C3F

Molecular Formula

C24H25BrF2N4O2S

Molecular Weight

551.45

References & Citations

[1]Niazi, et al. "Synthesis, characterization, and anti-cancer potential of novel p53-mediated Mdm2 and Pirh2 modulators: an integrated In silico and In vitro approach." Frontiers in Chemistry 12 (2024) : 1366370.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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