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Recombinant human Eukaryotic translation initiation factor 4E-binding protein 2

CAT: 0247-OPCA00077-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OPCA00077-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9000-83-3
Gene Name
Eukaryotic translation initiation factor 4E binding protein 2
Gene Aliases
4EBP2;4E-BP2; eIF4E-binding protein 2; eukaryotic translation initiation factor 4E-binding protein 2; PHASII; phosphorylated, heat and acid stable regulated by insulin protein II.
Gene ID
1979
Reactivity
Homo sapiens|Human
Target
Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity) . Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957) . EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity) . Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity) .
Type
Protein
Source
E.coli
Sequence
MSSSAGSGHQPSQSRAIPTRTVAISDAAQLPHDYCTTPGGTLFSTTPGGTRIIYDRKFLLDRRNSPMAQTPPCHLPNIPGVTSPGTLIEDSKVEVNNLNNLNNHDRKHAVGDDAQFEMDI
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid or Lyophilized powder
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
-20°C or -80°C
Molecular Weight
39.9 kDa
Protein Length
Recombinant
NCBI Gene Symbol
EIF4EBP2
Protein Name
Eukaryotic translation initiation factor 4E-binding protein 2
Gene Name URL
EIF4EBP2

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Alternative Products

CatalogName
0299244E-BP1 (Eukaryotic translation initiation factor 4E binding protein 1)
302413EIF4EBP3 (4E BP3, 4E-BP3, 4EBP3, eIF4E Binding Protein 3, Eukaryotic initiation Factor 4E Binding Protein 3, Eukaryotic translation initiation Factor 4E Binding Protein 3)
P9108-50DProtein Synthesis Initiation Factor 4E (eIF 4E, Eukaryotic Translation Initiation Factor)
MBS6257517-01EIF4EBP3 (4E BP3, 4E-BP3, 4EBP3, eIF4E Binding Protein 3, Eukaryotic initiation Factor 4E Binding Protein 3, Eukaryotic translation initiation Factor 4E Binding Protein 3) (APC)
MBS6257613-01EIF4EBP3 (4E BP3, 4E-BP3, 4EBP3, eIF4E Binding Protein 3, Eukaryotic initiation Factor 4E Binding Protein 3, Eukaryotic translation initiation Factor 4E Binding Protein 3) (HRP)
MBS6257581-01EIF4EBP3 (4E BP3, 4E-BP3, 4EBP3, eIF4E Binding Protein 3, Eukaryotic initiation Factor 4E Binding Protein 3, Eukaryotic translation initiation Factor 4E Binding Protein 3) (FITC)
MBS6257549-01EIF4EBP3 (4E BP3, 4E-BP3, 4EBP3, eIF4E Binding Protein 3, Eukaryotic initiation Factor 4E Binding Protein 3, Eukaryotic translation initiation Factor 4E Binding Protein 3) (Biotin)
MBS6257485-01EIF4EBP3 (4E BP3, 4E-BP3, 4EBP3, eIF4E Binding Protein 3, Eukaryotic initiation Factor 4E Binding Protein 3, Eukaryotic translation initiation Factor 4E Binding Protein 3) (AP)
MBS6257645-01EIF4EBP3 (4E BP3, 4E-BP3, 4EBP3, eIF4E Binding Protein 3, Eukaryotic initiation Factor 4E Binding Protein 3, Eukaryotic translation initiation Factor 4E Binding Protein 3) (PE)
315359-01Eukaryotic translation initiation factor 4E-binding Protein 2

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