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TGFBR2 ELISA Kit (Human)

CAT: 0247-OKBB00939-96WSize: 96 Well With Removable StripsDry Ice: NoHazardous: No
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CAT#:0247-OKBB00939-96WSize:96 Well With Removable Strips
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Reproducibility
Intra-Assay Precision Inter-Assay Precision Sample 1 2 3 1 2 3 n 16 16 16 24 24 24 Mean (pg/ml) 33 179 421 30 166 392 Standard deviation 2.34 8.23 18.1 2.31 8.3 21.16 CV (%) 7.1 4.6 4.3 7.7 5 5.4 Intra-Assay Precision Inter-Assay Precision Intra-Assay Precision Inter-Assay Precision Sample 1 2 3 1 2 3 Sample 1 2 3 1 2 3 n 16 16 16 24 24 24 n 16 16 16 24 24 24 Mean (pg/ml) 33 179 421 30 166 392 Mean (pg/ml) 33 179 421 30 166 392 Standard deviation 2.34 8.23 18.1 2.31 8.3 21.16 Standard deviation 2.34 8.23 18.1 2.31 8.3 21.16 CV (%) 7.1 4.6 4.3 7.7 5 5.4 CV (%) 7.1 4.6 4.3 7.7 5 5.4
CAS Number
7732-18-5
Gene Name
Transforming growth factor, beta receptor II (70/80kDa)
Gene Aliases
AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TbetaR-II, TGF-beta receptor type II, TGF-beta receptor type-2, TGF-beta type II receptor, TGFbeta RII, Tgfbr2, TGFR 2, TGFR-2, TGFR2_HUMAN, Transforming growth factor beta receptor II (70/80kDa), Transforming growth factor-beta receptor type II
Gene ID
7048
Accession Number
NP_001020018.1
Reactivity
Human
Immunogen
Expression system for standard: NS0; Immunogen sequence: I24-D159
Target
TGFBR2 (transforming growth factor, beta receptor II (70/80kDa) ), also known as TGF-beta receptor type-2, TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II (TGF-beta receptor type II, TbetaR-II), is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. A TGFBR2 cDNA encoding a deduced 565-amino acid protein with a calculated molecular mass of approximately 60 kD in length. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different informs have been characterized. TGFBR2 may be a target of the EWS-FLI1 fusion protein found in Ewing sarcoma and related peripheral primitive neuroectodermal tumors.
Type
ELISA Kit
Applications
ELISA
Assay Principle
Aviva's human TGFBR2 ELISA Kit was based on standard sandwich enzyme-linked immune-sorbent assay technology. A polyclonal antibody from goat specific for TGFBR2 has been precoated onto 96-well plates. Standards (NS0, I24-D159) and test samples are added to the wells, a biotinylated detection polyclonal antibody from goat specific for TGFBR2 is added subsequently and then followed by washing with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex was added and unbound conjugates were washed away with PBS or TBS buffer. HRP substrate TMB was used to visualize HRP enzymatic reaction. TMB was catalyzed by HRP to produce a blue color product that changed into yellow after adding acidic stop solution. The absorbance of yellow is proportional to the human TGFBR2 amount of sample captured in plate.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Sample Type
Cell culture supernates, cell lysates, serum and plasma (heparin, EDTA)
Detection Range
15.6 pg/ml - 1,000 pg/ml
Sensitivity
<10 pg/ml
Reconstitution
Store at 4C for 6 months, at -20C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.)
Specificity
Natural and recombinant human TGFBR2
NCBI Gene Symbol
TGFBR2
Protein Name
TGF-beta receptor type-2
Gene Name URL
TGFBR2
Nucleotide Accession Number
NM_001024847.2

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