PPARD Antibody

• Gene Name:

  Peroxisome proliferator activated receptor delta

• Gene Aliases:

  FAAR, NUC1, NUCI, NR1C2, NUCII, PPARB

• Gene ID:

  5467

• Accession Number:

  NP_001165289.1

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant Protein of PPAR Delta

• Target:

  This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.

• Clonality:

  Monoclonal

• Type:

  Monoclonal Antibody

• Applications:

  IHC

• Purification:

  The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/ml

• Format:

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Reconstitution:

  Store at -20C. Avoid repeated freeze/thaw cycles.

• Fragment:

  IgG1

• Specificity:

  PPAR Delta Mouse Monoclonal Antibody (2F9) detects endogenous levels of PPAR Delta

• NCBI Gene Symbol:

  PPARD

• Host or Source:

  Mouse

• Protein Name:

  Peroxisome proliferator-activated receptor delta

• Gene Name URL:

  PPARD

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_001171818.1