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Human CD45/LCA Antibody

CAT: 0247-OASB01103-100UGSize: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0247-OASB01103-100UGSize:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Receptor-type tyrosine-protein phosphatase C
Gene Aliases
LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180
Gene ID
5788; 100061950
Accession Number
NP_002829.3
Reactivity
Human
Immunogen
Purified T cells from human lymph nodes
Target
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Clonality
Monoclonal
Clone
F10-89-4
Conjugation
Unconjugated
Type
Monoclonal Antibody
Applications
FC, IHC-F, ICC, IP, WB
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.1 mg/mL
Dilution
6 cells 10 uL/106 cells 10 uL/106 cells 10 uL/106 cells 10 uL/106 cells 10 uL/106 cells 10 uL/106 cells 10 uL/106 cells 10 uL/106 cells66666666
Reconstitution
Store at 2-8C
Notes
Formerly GWB-E06268
Fragment
IgG2a
Specificity
CD45
NCBI Gene Symbol
PTPRC
Host or Source
Mouse
Protein Name
Receptor-type tyrosine-protein phosphatase C
Gene Name URL
PTPRC
Nucleotide Accession Number
NM_002838.4

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