Human CD35 Antibody

• Gene Name :

  Complement receptor type 1

• Gene Aliases :

  KN, C3BR, C4BR, CD35

• Gene ID :

  1378; 718120; 102117401; 449643; 101016492

• Accession Number :

  NP_000564.2

• Reactivity :

  Human

• Immunogen :

  Acute monocytic leukemia cells and normal blood monocytes

• Target :

  This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.

• Clonality :

  Monoclonal

• Clone :

  E11

• Conjugation :

  Unconjugated

• Type :

  Monoclonal Antibody

• Applications :

  FC, IHC-F, IHC-P, IP, WB

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  0.1 mg/mL

• Dilution :

  6 cells 10 uL/106 cells 10 uL/106 cells66

• Reconstitution :

  Store at 2-8C

• Fragment :

  IgG1

• Specificity :

  CD35

• NCBI Gene Symbol :

  CR1

• Host or Source :

  Mouse

• Protein Name :

  Complement receptor type 1

• Gene Name URL :

  CR1

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_000573.3