P2rx7 Antibody

• Gene Aliases:

  P2X, P2X (7, P2X7R, P2X (7), AI467586

• Gene ID:

  18439

• Accession Number:

  NP_035157.2

• Reactivity:

  Mouse

• Immunogen:

  A P2X7-expression construct and a final boost with P2X7-transfected HEK cells.

• Clonality:

  Monoclonal

• Clone:

  Hano43

• Type:

  Monoclonal Antibody

• Applications:

  Flow cytometry|Immunofluorescence

• Purification:

  Protein G Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/ml

• Homology:

  Mouse

• Format:

  Liquid. Phosphate buffered saline

• Reconstitution:

  -20°C

• Notes:

  Formerly GWB-Q01561

• Fragment:

  IgG2b

• Specificity:

  OASA05733 recognises the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.

• Protein Length:

  595

• NCBI Gene Symbol:

  P2RX7

• Host or Source:

  Rat

• Protein Name:

  P2X purinoceptor 7

• Gene Name URL:

  P2rx7

• CAS Number:

  9007-83-4