CCDC98 Antibody

• Gene Name:

  Abraxas 1, BRCA1 A complex subunit

• Gene Aliases:

  ABRA1; abraxas protein; BRCA1-A complex subunit Abraxas 1; CCDC98; coiled-coil domain containing 98; Coiled-coil domain-containing protein 98; FAM175A; family with sequence similarity 175 member A; Protein FAM175A.

• Gene ID:

  84142

• Accession Number:

  https://www.ncbi.nlm.nih.gov/protein/NP_620775

• Reactivity:

  Bovine|Chicken|Human|Mouse|Rat

• Immunogen:

  CCDC98 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human CCDC98. The immunogen is located within amino acids 80 - 130 of CCDC98.

• Target:

  Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  Enzyme-linked immunosorbent assay|Immunohistochemistry-Paraffin|Western blot

• Purification:

  Affinity Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/ml

• Homology:

  Human; Mouse

• Format:

  Liquid. CCDC98 Antibody is supplied in PBS containing 0.02% sodium azide.

• Reconstitution:

  CCDC98 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• NCBI Gene Symbol:

  ABRAXAS1

• Host or Source:

  Rabbit

• Protein Name:

  BRCA1-A complex subunit Abraxas 1|BRCA1-A complex subunit Abraxas 1 isoform 1 [Homo sapiens]

• Gene Name URL:

  ABRAXAS1

• CAS Number:

  9007-83-4