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Aph-1 Antibody

CAT: 0247-OAPB00475-100UGSize: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0247-OAPB00475-100UGSize:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
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CAS Number
9007-83-4
Gene Name
Aph-1 homolog A, gamma-secretase subunit
Gene Aliases
6530402N02Rik; anterior pharynx defective 1 homolog A; APH-1; APH-1A; APH1A gamma secretase subunit; aph-1alpha; CGI-78; gamma-secretase subunit APH-1A; presenilin-stabilization factor.
Gene ID
51107
Accession Number
https://www.ncbi.nlm.nih.gov/protein/AAH08732
Reactivity
Human|Mouse
Immunogen
APH1 antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human APH1a. The immunogen is located within amino acids 40 - 90 of APH1.
Target
Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12297508, PubMed:12522139, PubMed:12763021, PubMed:12679784, PubMed:25043039, PubMed:26280335) . Required for normal gamma-secretase assembly (PubMed:12522139, PubMed:12471034, PubMed:12763021, PubMed:19369254) . The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Western blot
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Homology
Human; Mouse
Format
Liquid. APH1 Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution
APH1 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
NCBI Gene Symbol
APH1A
Host or Source
Rabbit
Protein Name
Anterior pharynx defective 1 homolog A (C. elegans) [Homo sapiens]|Gamma-secretase subunit APH-1A
Gene Name URL
APH1A
Nucleotide Accession Number
NM_001273034.1NM_134866.3

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