RAD50 Antibody

• Gene Name :

  RAD50 double strand break repair protein

• Gene Aliases :

  NBSLD, RAD502, hRad50

• Gene ID :

  10111

• Accession Number :

  NP_005723.2

• Reactivity :

  Human, Mouse, Rat, Monkey

• Immunogen :

  Amino acids 1-425 of Rad50 expressed in E. coli.

• Target :

  The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

• Clonality :

  Monoclonal

• Clone :

  13B3

• Type :

  Monoclonal Antibody

• Applications :

  ICC, IF, IHC, IHC-P, IP, WB

• Purification :

  Protein G purified

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  1.38 mg/ml

• Format :

  Liquid

• Buffer :

  PBS

• Reconstitution :

  Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

• Fragment :

  IgG1

• NCBI Gene Symbol :

  RAD50

• Host or Source :

  Mouse

• Protein Name :

  DNA repair protein RAD50

• Gene Name URL :

  RAD50

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_005732.3