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MRE11 Antibody

CAT: 0247-OAGA08768-100ULSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0247-OAGA08768-100ULSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
MRE11 homolog, double strand break repair nuclease
Gene Aliases
ATLD, HNGS1, MRE11A, MRE11B
Gene ID
4361
Accession Number
NP_005581.2
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 182-582 of Mre11 expressed in E. coli.
Target
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Clonality
Monoclonal
Clone
12D7
Type
Monoclonal Antibody
Applications
ICC, IF, IHC-P, IP, WB, FN
Purification
Protein G purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1.89 mg/ml
Format
Liquid
Buffer
PBS
Reconstitution
Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.
Fragment
IgG1
NCBI Gene Symbol
MRE11
Host or Source
Mouse
Protein Name
Double-strand break repair protein MRE11; double-strand break repair protein MRE11A
Gene Name URL
MRE11
Nucleotide Accession Number
NM_005590.3