COPS5 Antibody

• Gene Name:

  COP9 signalosome subunit 5

• Gene Aliases:

  CSN5, JAB1, SGN5, MOV-34

• Gene ID:

  10987

• Accession Number:

  NP_006828.2

• Reactivity:

  Human, Mouse

• Immunogen:

  The full-length mouse JAB-1 gene expressed in E. coli.

• Target:

  The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.

• Clonality:

  Monoclonal

• Clone:

  6C3.38

• Type:

  Monoclonal Antibody

• Applications:

  IHC, IP, WB

• Purification:

  Protein G purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/ml

• Format:

  Liquid

• Buffer:

  Phosphate-buffered saline, pH 7.4, containing no preservatives

• Reconstitution:

  Keep as concentrated solution. Store at 4C short term. For extended storage aliquot and store at -20C or below. Avoid freeze-thaw cycles.

• Fragment:

  IgG2a

• NCBI Gene Symbol:

  COPS5

• Host or Source:

  Mouse

• Protein Name:

  COP9 signalosome complex subunit 5

• Gene Name URL:

  COPS5

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_006837.2