BRCA1 Antibody

• CAS Number :

  9007-83-4

• Gene Name :

  BRCA1, DNA repair associated

• Gene Aliases :

  IRIS, PSCP, BRCAI, BRCC1, FANCS, PNCA4, RNF53, BROVCA1, PPP1R53

• Gene ID :

  672

• Accession Number :

  NP_009225.1

• Reactivity :

  Human, Mouse

• Immunogen :

  Protein fragment expressed in E. coli corresponding to amino acids 341-748.

• Target :

  BRCA1-8F7 recognizes full-length BRCA1, a 220kDa nuclear phosphoprotein. In a high proportion of breast and ovarian cancer cell lines, BRCA1 aberrantly mislocates to the cytoplasm. Its usefulness to monitor functional inactivation of BRCA1 in sporadic breast cancers is under active investigation.

• Clonality :

  Monoclonal

• Clone :

  8F7

• Type :

  Monoclonal Antibody

• Applications :

  WB, IHC-P, IP

• Purification :

  Protein G purified

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  1 mg/ml

• Format :

  Liquid.// PBS

• Reconstitution :

  Keep as concentrated solution. Store at 4° C short term. For extended storage aliquot and store at -20° C or below. Avoid freeze-thaw cycles.

• Molecular Weight :

  220 kDa

• Fragment :

  IgG1

• Specificity :

  This antibody recognizes full-length BRCA1, a 220-kDa nuclear phosphoprotein. Mutations in this tumor suppressor gene greatly increase the risk of breast cancer.

• NCBI Gene Symbol :

  BRCA1

• Host or Source :

  Mouse

• Protein Name :

  Breast cancer type 1 susceptibility protein

• Gene Name URL :

  BRCA1

• Nucleotide Accession Number :

  NM_007294.3