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BRCA1 Antibody

CAT: 0247-OAGA08724-100ULSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0247-OAGA08724-100ULSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
BRCA1, DNA repair associated
Gene Aliases
IRIS, PSCP, BRCAI, BRCC1, FANCS, PNCA4, RNF53, BROVCA1, PPP1R53
Gene ID
672
Accession Number
NP_009225.1
Reactivity
Human, Mouse
Immunogen
Protein fragment expressed in E. coli corresponding to amino acids 341-748.
Target
BRCA1-8F7 recognizes full-length BRCA1, a 220kDa nuclear phosphoprotein. In a high proportion of breast and ovarian cancer cell lines, BRCA1 aberrantly mislocates to the cytoplasm. Its usefulness to monitor functional inactivation of BRCA1 in sporadic breast cancers is under active investigation.
Clonality
Monoclonal
Clone
8F7
Type
Monoclonal Antibody
Applications
WB, IHC-P, IP
Purification
Protein G purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid.// PBS
Reconstitution
Keep as concentrated solution. Store at 4° C short term. For extended storage aliquot and store at -20° C or below. Avoid freeze-thaw cycles.
Molecular Weight
220 kDa
Fragment
IgG1
Specificity
This antibody recognizes full-length BRCA1, a 220-kDa nuclear phosphoprotein. Mutations in this tumor suppressor gene greatly increase the risk of breast cancer.
NCBI Gene Symbol
BRCA1
Host or Source
Mouse
Protein Name
Breast cancer type 1 susceptibility protein
Gene Name URL
BRCA1
Nucleotide Accession Number
NM_007294.3

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